By Nicolas Hulscher, MPH

In a groundbreaking landmark study titled “Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence from New-Onset Adverse Events and Cancers Post-Vaccination”—just uploaded to Preprints.org—we discovered that COVID-19 mRNA injections can trigger profound, long-lasting genetic dysregulation in individuals who develop new-onset adverse events or cancer following vaccination.

The study was conducted by scientists from Neo7Bioscience (Dr. John Catanzaro, Dr. Natalia von Ranke, Dr. Wei Zhang, Dr. Philipp Anokin), the University of North Texas (Dr. Danyang Shao, Dr. Ahmad Bereimipour, Minh Vu), the McCullough Foundation (Dr. Peter McCullough and Nicolas Hulscher) and Medicinal Genomics (Kevin McKernan).

Using high-resolution RNA sequencing of blood samples and differential gene expression analysis, we found that COVID-19 “vaccines” severely disrupted the expression of thousands of genes—inducing mitochondrial failure, immune system reprogramming, and oncogenic activation that persisted for months to years after injection.

METHODS

The study analyzed whole blood RNA profiles from:

• 3 patients with new-onset adverse events (neurological, cardiovascular, chronic fatigue) following mRNA vaccination

• 7 patients newly diagnosed with cancer post-mRNA vaccination

• 803 healthy controls

Key tools and analyses:

• Bulk RNA sequencing (Illumina NextSeq) of patient blood samples

• DESeq2 for differential gene expression analysis

• Gene Set Enrichment Analysis (GSEA) to identify disrupted biological pathways

• STRING + Cytoscape to visualize protein-protein interaction (PPI) networks of dysregulated genes

FINDINGS

mRNA Vaccines Trigger Transcriptomic Chaos

Both vaccine injured groups showed massive gene dysregulation compared to healthy controls—hundreds of genes up- or down-regulated, especially in pathways tied to:

• Mitochondrial dysfunction

• Protein folding and degradation stress (proteasome pathways)

• Ribosomal overload and nonsense-mediated decay (NMD)

• Chronic systemic inflammation

• Oncogenic activation (MYC) and tumor suppressor suppression (p53, KRAS)

Shared Hallmarks in Both Groups

• Mitochondrial Dysfunction & Oxidative Stress
  Complex I disruptions and ROS overproduction—core features of chronic fatigue and neurodegeneration.

• Ribosomal Stress & Translational Overdrive
  Synthetic mRNA with modified bases (N1-methylpseudouridine) appears to trigger ribosomal overload, translation errors, and RNA surveillance activation. These stress signatures are also consistent with host responses to foreign genetic material, and may reflect reverse transcription of mRNA via endogenous LINE-1 activity, residual plasmid DNA, or vector-derived promoter activity—raising the possibility of persistent transcription or genomic integration.

• Proteasome Activation
  Likely due to spike protein persistence and accumulation of misfolded proteins.

• Endothelial Dysfunction & Coagulopathy
  Genes regulating angiogenesis and coagulation were downregulated—mirroring thrombotic complications post-vaccination.

• Oncogenic Signals
  Activation of MYC, suppression of p53 and KRAS inhibitors, setting the stage for tumor growth.

Cancer Group Shows Additional Red Flags

• Genomic Instability & Epigenetic Reprogramming
  Strong upregulation of genes linked to chromatin remodeling, DNA methylation, and nucleosome displacement—hallmarks of early tumorigenesis.

• Hyperactivation of Type I Interferon and Toll-like Receptor (TLR) Pathways
  Persistent immune system stimulation via TLRs, IRFs, and JAK-STAT—common in both chronic inflammation and cancer immune escape.

• ACE2 Downregulation
  Both groups showed severe suppression of ACE2, activating the Ang II → AT1R → NF-κB/MAPK cascade—a known tumor-promoting and inflammatory loop.

To our knowledge, this is the first study to show long-term genetic disruption in individuals harmed by the COVID-19 mRNA injections.

These findings strongly suggest:

• mRNA vaccines can induce gene expression profiles consistent with tumor formation and chronic disease

• mRNA-vaccinated individuals may be at heightened risk of cancer, immune dysfunction, and inflammatory disorders

• The synthetic mRNA and long-lasting spike protein appear to create sustained cellular stress that disrupts normal genetic regulation

• Signatures suggest potential reverse transcription of vaccine mRNA and persistence of plasmid DNA—raising concern for long-term transcriptional interference or possible genomic integration

It’s time for the immediate withdrawal of these dangerous gene therapies to protect the remaining ~20% of the population still considering booster doses.

von Ranke N, Zhang W, Anokin P, Shao D, Bereimipour A, Vu M, Hulscher N, McKernan KJ, McCullough PA, Catanzaro JA. Synthetic mRNA Vaccines and Transcriptomic Dysregulation: Evidence From New-Onset Adverse Events and Cancers Post-Vaccination. Preprints. 2025;2025072155. doi:10.20944/preprints202507.2155.v1

Nicolas Hulscher, MPH

Epidemiologist and Foundation Administrator, McCullough Foundation

http://www.mcculloughfnd.org

Please consider following both the McCullough Foundation and my personal account on X (formerly Twitter) for further content.

 

IPAK-EDU is grateful to FOCAL POINTS (Courageous Discourse) as this piece was originally published there and is included in this news feed with mutual agreement. Read More